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LS:TANG Lixia

published: 2015-12-10 09:58:51       hits: 

name : TANG Lixia Gender: female phone: 028-83208232
email: lixiatang@uestc.edu.cn office-address: Main Building 354, ShaHe Campus
PH.D  Supervisor: No Master Supervisor Yes
major: Protein engineering and biocatalysis
research interest: Current research interests: enzymological and protein engineering studies on microbial enzymes that can be used as biocatalysts in the synthesis of fine chemicals; new enzyme discovery by metagenomic technique; wastewater treatment using immobilized enzyme and bacterial cells.
Biography: Prof. Tang received her Ph.D. degree in Biomolecular Sciences and Technology Institute, Groningen University, The Netherlands, in 2004. Afterwards, she worked at the same insitute as a postdocfor 1.5 year. From 2006 till now, she works at School of Life Science and Technology, University of Electronic Science and Technology of China. 
Teaching Schedule: Protein purification techniques (under graduated students) (spring)
Advanced Molecular Biology (graduated/Ph.D. students) (fall)
Advanced Molecular Biology (international graduated/Ph.D. students) (fall)
Selected Publications: 1. Wang, X.,  Zheng, Z., Zheng, H., Nie, H., Yang, Z., and Tang, L.* (2014) DC-Analyzer-facilitated combinatorial strategy for rapid directed evolution of functional enzymes with multiple mutagenesis sites. J. Biotechnol. 192:102-107
2.  Tang, L*., Liu, Y., Jiang, R., Zheng, Y., Zheng, K., and Zheng, H. (2014) A high-throughput adrenaline test for the exploration of the catalytic potential of halohydrin dehalogenases in epoxide-ring opening reactions. Biotechnol. Appl. Biochem. doi: 10.1002/bab.1278.
3. Tang, L*., Wang, X., Ru, B., Sun, H., Huang, H. and Gao, H. (2014) MDC-Analyzer: a novel degenerate primer design tool for the construction of intelligent mutagenesis libraries with contiguous sites. BioTechniques, 56:301-310..
4. Tang, L*., Zheng, K., Liu, Y., Zheng, Z., Wang, H., Song, C. and Zhou, H. (2013) Exploring the potential of megaprimer PCR in coupling with orthogonal array design for mutagenesis library. Biotechnol. Appl. Biochem. 60:190-195.
5. Bai, Y., Feng, J., Ma, H., Lin, J., Han, S., and Tang, L. (2013) Role of the CPC sequence in the antioxidant activity of GcGAST protein in E.coli. Protein J. 32: 48-57.
6. Majerić Elenkov, M., Primožič, I., Hrenar, T., Smolko, A., Dokli, I., Salopek-Sondi, B. and Tang, L. (2012) Catalytic activity of halohydrin dehalogenases towards spiroepoxides Org. and Biomol. Chem. 10:5063-5072.
7. Tang, L*., Gao, H., Zhu, X., Wang, X., Zhou, M. and Jiang, R. (2012) Construction of ‘small-intelligent’ focused mutagenesis libraries using well-designed combinatorial degenerate primers. BioTechniques 52:149-158.
8. Tang, L*., Zhu, X., Zheng, H., Jiang, R. and Majerić Elenkov, M. (2012) Key residues for controlling enantioselectivity of halohydrin dehalogenase from Arthrobacter sp. AD2 revealed by structure-guided directed evolution. Appl. Environ. Microb.78:2631-2637.
9. Tang, L*., Jiang, R., Zheng, K. and Zhu, X. (2011) Enhancing the recombinant protein expression of halohydrin dehalogenase HheA in Escherichia coli by applying a codon optimization strategy. Enzyme Microb.Technol. 49: 395-401.
10. Tang, L., Li, L., and Wang, X. (2010) A high-throughput colorimetric assay for screening halohydrin dehalogenase saturation mutagenesis libraries. J. Biotechnol. 147, 164-168.